Non-catalytic addition of 1,2,4-triazole to nucleophilic and electrophilic alkenes

被引：0

作者：

Timokhin B.V. ^{[1
]}

Golubin A.I. ^{[1
]}

Vysotskaya O.V. ^{[2
]}

Kron V.A. ^{[1
]}

Oparina L.A. ^{[2
]}

Gusarova N.K. ^{[2
]}

Trofimov B.A. ^{[2
]}

机构：

[1] Irkutsk State University

[2] A. E. Favorsky Irkutsk Inst. Chem., Siberian Branch, Russian Academy of Sciences

来源：

Chemistry of Heterocyclic Compounds | 2002年 / 38卷 / 08期

关键词：

1,2,4-triazole; 4-phenyl-3-buten-2-one; Acrylic acid; Acrylonitrile; Addition; Markovnikov and anti-Markovnikov adducts; Vinyl ethers;

D O I：

10.1023/A:1020981816097

中图分类号：

O62 [有机化学]; TQ [化学工业];

学科分类号：

070303 ; 0817 ; 081704 ;

摘要：

Non-catalytic addition of 1,2,4-triazole to vinyl ethers and esters occurs on heating (65-175°C, 4-20 h) to give Markovnikov adducts (yield 30-100%). Electron-deficient alkenes (acrylonitrile, acrylic acid, 4-phenyl-3-buten-2-one) react with 1,2,4-triazole (78-190°C, 4-20 h) to give anti-Markovnikov adducts in yields of 45-83%.

引用

页码：981 / 985

页数：4