Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 1,2,3-Triazole Tagged 5-[(1H-Indol-3-yl)methylene]pyrimidine-2,4,6(1H,3H,5H)trione Derivatives

被引：0
作者：
Ashok Kumar
B. Sathish Kumar
E. Sreenivas
T. Subbaiah
机构：
[1] Sreenidhi Institute of Science and Technology,Department of Chemistry
[2] Osmania University,Department of Chemistry
[3] Averin Biotech Pvt. Ltd. Windsorplaza,Bioinformatics Division
[4] Koneru Lakshmaiah Deemed to be University,Department of Chemistry
来源：
Russian Journal of General Chemistry | 2018年 / 88卷
关键词：
1,2,3-triazole; indole; click reaction; cervical cancer; molecular docking;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Novel 5-{(1-[(1-phenyl-1H-1,2,3-triazol-4-yl)methyl]-1H-indol-3-yl)methylene}pyrimidine-2,4,6-(1H,3H,5H)trione derivatives (5a–5k) were synthesized by the click reaction. All compounds 5a–5k were characterized by 1H and 13C NMR, IR and Mass spectra and evaluated for their in vitro anticancer activity against cervical cancer cell lines. Among all, compound 5e (IC50 = 6.76 μM), shown high inhibitory activity. Docking analysis of all the compounds with the Lipid kinase PI3K-α revealed that the compound 5e fitted well in the active site pocket, showing the best docking score (LibDock) of 123.274.
引用
收藏
页码：587 / 595
页数：8
相关论文
共 172 条
[1]  
De Simone R.W.(2004)undefined Comb. Chem. High. Throughput Screen. 7 473-undefined
[2]  
Currie K.S.(2009)undefined Bioorg. Med. Chem. Lett. 19 3054-undefined
[3]  
Mitchell S.A.(2013)undefined Appl. Biochem. Biotechno. 171 2030-undefined
[4]  
Darrow J.W.(2008)undefined Lett. Drug. Des. Discov. 5 286-undefined
[5]  
Pippin D.A.(2007)undefined Chin. J. Chem. 25 382-undefined
[6]  
Singh P.(2006)undefined Eur. J. Med. Chem 41 1223-undefined
[7]  
Kaur M.(2003)undefined Tetrahedron. 59 3427-undefined
[8]  
Verma P.(2010)undefined Bioorg. Med. Chem. Lett. 20 600-undefined
[9]  
Sokmen B.B.(2011)undefined Bioorg. Med. Chem. 19 4985-undefined
[10]  
Ugras S.(2008)undefined J. Med. Chem. 51 4563-undefined
12345678910