Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

被引:0
|
作者
Xiaoqing Li
Xinxin Li
Genbei Wang
Yan Xu
Yuanyuan Wang
Ruijia Hao
Xiaohui Ma
机构
[1] Tasly Pharmaceutical Co.,Department of Pharmacology and Toxicology
[2] Ltd.,undefined
来源
Frontiers of Medicine | 2018年 / 12卷
关键词
XKQ; type 2 diabetes mellitus; KKAy mice; PI3K/Akt pathway; diabetic liver disease;
D O I
暂无
中图分类号
学科分类号
摘要
Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10 years in Chinese traditional medication. However, its mechanisms against hyperglycemia remain poorly understood. This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAy mice model. Our results indicate that XKQ can significantly reduce food and water intake. XKQ treatment also remarkably decreases both the fasting blood glucose and blood glucose in the oral glucose tolerance test. Additionally, XKQ can significantly decrease the serum alanine aminotransferase level and liver index and can alleviate the fat degeneration in liver tissues. Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-Akt, and GLUT4 in the skeletal muscle of KKAy mice. XKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling pathway in the skeletal muscle.
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页码:688 / 696
页数:8
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