Synthesis and antituberculosis activity of conjugates of the diterpenoid isosteviol and the drug dimephosphon

被引：0
作者：
B. F. Garifullin
R. V. Chestnova
V. F. Mironov
V. E. Kataev
机构：
[1] A. E. Arbuzov Institute of Organic and Physical Chemistry,
[2] Kazan Scientific Center,undefined
[3] Russian Academy of Sciences,undefined
[4] Republic Clinical Antituberculosis Dispensary,undefined
[5] Ministry of Health,undefined
来源：
Chemistry of Natural Compounds | 2012年 / 48卷
关键词：
diterpenoids; isosteviol; dimephosphon; antituberculosis activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Conjugates of the diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) and the drug dimephosphon (1,1dimethyl-3-oxobutylphosphonic acid dimethyl ester) were synthesized. They inhibited completely growth of M. tuberculosis (H37Rv, in vitro) with MIC values of 5–10 μg/mL (MIC value of the antituberculosis drug isoniazid in a control was 0.5 μg/mL).
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页码：794 / 798
页数：4
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