Extracellular Signal-Regulated Kinase in Nucleus Accumbens Mediates Propofol Self-Administration in Rats

被引：0
作者：
Benfu Wang
Xiaowei Yang
Anna Sun
Lanman Xu
Sicong Wang
Wenxuan Lin
Miaojun Lai
Huaqiang Zhu
Wenhua Zhou
Qingquan Lian
机构：
[1] the Second Affiliated Hospital of Wenzhou Medical University,Department of Anesthesiology and Pain Medicine
[2] Ningbo University,Laboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, School of Medicine
[3] the First Affiliated Hospital of Wenzhou Medical University,Department of Infection and Liver Diseases
来源：
Neuroscience Bulletin | 2016年 / 32卷
关键词：
Dopamine receptor; Drug reward; ERK; Anesthesiology; Nucleus accumbens;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Clinical and animal studies have indicated that propofol has potential for abuse, but the specific neurobiological mechanism underlying propofol reward is not fully understood. The purpose of this study was to investigate the role of extracellular signal-regulated kinase (ERK) signal transduction pathways in the nucleus accumbens (NAc) in propofol self-administration. We tested the expression of p-ERK in the NAc following the maintenance of propofol self-administration in rats. We also assessed the effect of administration of SCH23390, an antagonist of the D1 dopamine receptor, on the expression of p-ERK in the NAc in propofol self-administering rats, and examined the effects of intra-NAc injection of U0126, an MEK inhibitor, on propofol reinforcement in rats. The results showed that the expression of p-ERK in the NAc increased significantly in rats maintained on propofol, and pre-treatment with SCH23390 inhibited the propofol self-administration and diminished the expression of p-ERK in the NAc. Moreover, intra-NAc injection of U0126 (4 µg/side) attenuated the propofol self-administration. The data suggest that ERK signal transduction pathways coupled with D1 dopamine receptors in the NAc may be involved in the maintenance of propofol self-administration and its rewarding effects.
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页码：531 / 537
页数：6
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