Stimulation of Apolipoprotein A-IV expression in Caco-2/TC7 enterocytes and reduction of triglyceride formation in 3T3-L1 adipocytes by potential anti-obesity Chinese herbal medicines

被引：7
作者：
Guo A.J. [1 ]
Choi R.C.-Y. [1 ]
Cheung A.W.-H. [1 ]
Li J. [1 ]
Chen I.X. [1 ]
Dong T.T. [1 ]
Tsim K.W.-H. [1 ]
Lau B.W.-C. [2 ]
机构：
[1] Department of Biology, Center for Chinese Medicine, Hong Kong University of Science and Technology, Hong Kong, Clear Water Bay Road
[2] Macao Institute for Applied Research in Medicine Health (MUST Foundation), Taipa, Avenida Wai Long
来源：
Chinese Medicine | / 4卷 / 1期
关键词：
Ginsenoside; Chinese Medicinal Herb; Lipid Micelle; Chemical Cocktail; Danggui Buxue Tang;
D O I：
10.1186/1749-8546-4-5
中图分类号：
学科分类号：
摘要：
Background: Chinese medicine has been proposed as a novel strategy for the prevention of metabolic disorders such as obesity. The present study tested 17 Chinese medicinal herbs were tested for their potential anti-obesity effects. Methods: The herbs were evaluated in terms of their abilities to stimulate the transcription of Apolipoprotein A-IV (ApoA-IV) in cultured Caco-2/TC7 enterocytes. The herbs that showed stimulating effects on ApoA-IV transcription were further evaluated in terms of their abilities to reduce the formation of triglyceride in differentiated 3T3-L1 adipocytes. Results: ApoA-IV transcription was stimulated by Rhizoma Alismatis and Radix Angelica Sinensis in a dose- and time-dependent manner in cultured Caco-2/TC7 cells. Moreover, these two herbs reduced the amount of triglyceride in differentiated 3T3-L1 adipocytes. Conclusion: The results suggest that Rhizoma Alistmatis and Radix Angelica Sinensis may have potential anti-obesity effects as they stimulate ApoA-IV transcription and reduce triglyceride formation. © 2009 Guo et al; licensee BioMed Central Ltd.
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