FoxP3+ regulatory CD4 T cells control the generation of functional CD8 memory

被引：0
作者：
M.G. de Goër de Herve
S. Jaafoura
M. Vallée
Y. Taoufik
机构：
[1] INSERM U-1012,Department of Immunology
[2] Faculté de Médecine Paris-Sud,undefined
[3] Université Paris Sud,undefined
[4] Hôpitaux Universitaires Paris-Sud,undefined
[5] AP-HP,undefined
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Nature Communications | / 3卷
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摘要：
During the primary immune response, CD8 memory emerges from an environment of strong immune activation. The FoxP3+ regulatory CD4 T-cell subset (Treg) is known as a key suppressive component of the immune system. Here we report that Tregs are required for the generation of functional CD8 memory. In the absence of Tregs during priming, the resulting memory cells proliferate poorly and fail to differentiate into functional cytotoxic secondary effectors following antigen reactivation. We find that the Tregs act early, during the expansion phase of primary CD8 effectors, by fine tuning interleukin-2 exposure of CD8 memory precursors. This crucial new role of Tregs has implications for optimal vaccine development.
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[1]  
Williams MA(2007)Effector and memory CTL differentiation Annu. Rev. Immunol. 25 171-192
[2]  
Bevan MJ(2003)CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes Nature 421 852-856
[3]  
Janssen EM(2003)Requirement for CD4 T cell help in generating functional CD8 T cell memory Science 300 337-339
[4]  
Shedlock DJ(2004)CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection Nat. Immunol. 5 927-933
[5]  
Shen H(2000)Diminished primary and secondary influenza virus-specific CD8(+) T-cell responses in CD4-depleted Ig(−/−) mice J. Virol. 74 9762-9765
[6]  
Sun JC(2007)CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses J. Immunol. 179 8243-8251
[7]  
Williams MA(2003)HCV persistence and immune evasion in the absence of memory T cell help Science 302 659-662
[8]  
Bevan MJ(2008)Heterospecific CD4 help to rescue CD8 T cell killers J. Immunol. 181 5974-5980
[9]  
Riberdy JM(2006)IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation J. Immunol. 176 7288-7300
[10]  
Christensen JP(2001)Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells Nat. Immunol. 2 1010-1017
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