Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

Lohmueller KE(2007)New models of collaboration in genome-wide association studies: the Genetic Association Information Network Nat Genet 39 1045-51

Pearce CL(2003)Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease Nat Genet 33 177-182

Pike M(1995)Polygenic disease: methods for mapping complex disease traits Trends Genet 11 513-9

Lander ES(2009)Finding the missing heritability of complex diseases Nature 461 747-753

Hirschhorn JN(1992)Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction Nature 359 641-644

Weeks DE(1996)Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations Circulation 93 7-9

Lathrop GM(2005)Gene-environment interactions in human diseases Nat Rev Genet 6 287-98

Manolio TA(2007)Detection of gene x gene interactions in genome-wide association studies of human population data Hum Hered 63 67-84

Collins FS(2002)Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure N Engl J Med 347 1135-1142

Cox NJ(2002)Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma Am J Hum Genet 70 230-236

Lohmueller KE(2007)New models of collaboration in genome-wide association studies: the Genetic Association Information Network Nat Genet 39 1045-51

Pearce CL(2003)Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease Nat Genet 33 177-182

Pike M(1995)Polygenic disease: methods for mapping complex disease traits Trends Genet 11 513-9

Lander ES(2009)Finding the missing heritability of complex diseases Nature 461 747-753

Hirschhorn JN(1992)Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction Nature 359 641-644

Weeks DE(1996)Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations Circulation 93 7-9

Lathrop GM(2005)Gene-environment interactions in human diseases Nat Rev Genet 6 287-98

Manolio TA(2007)Detection of gene x gene interactions in genome-wide association studies of human population data Hum Hered 63 67-84

Collins FS(2002)Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure N Engl J Med 347 1135-1142

Cox NJ(2002)Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma Am J Hum Genet 70 230-236