Intermolecular interactions governing solubilization in micelles of poly(alkylene oxide) surfactants

被引:0
作者
V. S. Bugrin
M. Yu. Kozlov
I. I. Baskin
N. S. Melik-Nubarov
机构
[1] Moscow State University,Faculty of Chemistry
来源
Polymer Science Series A | 2007年 / 49卷
关键词
Porphyrin; Polymer Science Series; Pluronic; Alkylene Oxide; Hydrophobic Surface Area;
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摘要
Partition coefficients for 39 low-molecular-mass compounds between water and micelles of an ethylene oxide-propylene oxide block copolymer (Pluronic P85) and the monolauryl ether of poly(ethylene oxide) (Brij 35) have been measured by the methods of fluorescence spectroscopy, fluorescence anisotropy, and dialysis kinetics. The tested compounds include aromatic hydrocarbons, phenols, naphthols, xanthene dyes, anthracycline antibiotics, and porphyrins. The multifactor analysis of the partition coefficients in terms of the linear free-energy relationships has been performed. It has been shown that the H-donating ability of compounds facilitates their solubilization in Pluronic micelles and has no effect on solubilization in micelles of monolauryl ether of poly(ethylene oxide). This difference indicates that, when solubilization occurs in Pluronic micelles, the compounds under study appear in a hydrophobic core composed of poly(propylene oxide) blocks.
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页码:463 / 472
页数:9
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共 73 条
[1]  
Rangel-Yagui C. O.(2005)undefined J. Pharm. Pharm. Sci. 8 147-undefined
[2]  
Pessoa A.(2003)undefined J. Pharm. Sci. 92 1343-undefined
[3]  
Tavares L. C.(2003)undefined Proc. Natl. Acad. Sci. USA. 100 6039-undefined
[4]  
Adams M. L.(2001)undefined J. Controlled Release 73 137-undefined
[5]  
Lavasanifar A.(1995)undefined Anal. Chem. 67 499-undefined
[6]  
Kwon G. S.(1993)undefined Pure Appl. Chem. 65 2503-undefined
[7]  
Torchilin V. P.(1998)undefined Pharm. Res. 15 1525-undefined
[8]  
Lukyanov A. N.(1997)undefined Langmuir 13 3659-undefined
[9]  
Gao Z.(1993)undefined Macromolecules 26 5592-undefined
[10]  
Papahadjopoulos-Sternberg B.(2000)undefined Macromolecules 33 3305-undefined