Preoperative and adjuvant treatment of localized rectal cancer

被引：7

作者：

Das P. ^{[1
]}

Crane C.H. ^{[1
]}

机构：

[1] Department of Radiation Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030

来源：

Current Oncology Reports | 2006年 / 8卷 / 3期

关键词：

Rectal Cancer; Bevacizumab; Clin Oncol; Oxaliplatin; Capecitabine;

D O I：

10.1007/s11912-006-0016-6

中图分类号：

学科分类号：

摘要：

Although postoperative chemoradiation has a proven role in the treatment of stage II to III localized rectal cancer, recent trials have demonstrated the role of preoperative chemoradiation. A recent randomized trial has shown that preoperative chemoradiation yields higher rates of local control and sphincter preservation and lower rates of toxicity, compared with postoperative chemoradiation. Randomized trials have also shown that preoperative chemoradiation yields higher rates of pathologic complete response and local control, compared with radiotherapy alone. In this article, we review recent trials on preoperative and adjuvant therapy of localized rectal cancer. The roles of newer agents, such as capecitabine, oxaliplatin, and bevacizumab, are also discussed, and other key issues in the treatment of localized rectal cancer are reviewed. Copyright © 2006 by Current Science Inc.

引用

页码：167 / 173

页数：6

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