A complete response in small cell carcinoma of the esophagus treated by S-1/cisplatin combined chemotherapy and radiotherapy

被引：7
作者：
Hiraki M. [1 ]
Tanaka M. [1 ]
Sato S. [1 ]
Kai K. [2 ]
Morito K. [1 ]
Kobayashi K. [1 ]
Noshiro H. [1 ]
Tokunaga O. [2 ]
Miyazaki K. [1 ]
机构：
[1] Department of Surgery, Saga University, Faculty of Medicine, Saga 849-8501
[2] Department of Pathology and Biodefense, Saga University, Faculty of Medicine, Saga
来源：
Journal of Gastrointestinal Cancer | 2010年 / 41卷 / 4期
关键词：
chemotherapy; cisplatin; esophageal cancer; radiotherapy; S-1; small cell carcinoma;
D O I：
10.1007/s12029-010-9159-7
中图分类号：
学科分类号：
摘要：
Small cell carcinoma of the esophagus (SmCCE) is a rare disease which is considered to be more malignant than the most common types of esophageal cancer. The optimal treatment strategy for this disease still remains controversial. A 69-year-old male was diagnosed to have SmCCE (stage IIIA, T3N1M0). Due to the patient's poor general condition, chemo-radiotherapy consisting of S-1/cisplatin therapy and a total of 60 Gy of radiotherapy was performed. After the treatment, the main lesion completely disappeared while some ulceration remained. A histological examination revealed no viable cancer cells in biopsy specimens obtained by endoscopy. Computed tomographic examinations showed a decreased wall thickness of the esophagus and an improvement in the swelling of the lymph nodes. S-1 monotherapy was administered following the main chemoradiation therapy, and it was performed for a total of 20 courses. The patient has been doing well without recurrence for over 3 years. We judged the effect to be a complete response. This combination chemo-radiotherapy with S-1 and cisplatin may therefore be one of the effective treatments against SmCCE. © 2010 Springer Science+Business Media, LLC.
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页码：275 / 280
页数：5
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