Endogenous retroviruses in the origins and treatment of cancer

被引：0
作者：
Natasha Jansz
Geoffrey J. Faulkner
机构：
[1] Mater Research Institute - University of Queensland,Queensland Brain Institute
[2] University of Queensland,undefined
来源：
Genome Biology | / 22卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate expression from gene networks, including those underpinning embryogenesis and immune cell function. ERV activation can promote an interferon response, a phenomenon termed viral mimicry. Although ERV expression is associated with cancer, and provisionally with autoimmune and neurodegenerative diseases, ERV-mediated inflammation is being explored as a way to sensitize tumors to immunotherapy. Here we review ERV co-option in development and innate immunity, the aberrant contribution of ERVs to tumorigenesis, and the wider biomedical potential of therapies directed at ERVs.
引用
收藏
相关论文
共 910 条
[41]  
Flynn RA(2004)Human endogenous retrovirus K solo-LTR formation and insertional polymorphisms: implications for human and viral evolution Proc Natl Acad Sci U S A. 101 1668-1116
[42]  
Chavez SL(2017)DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats Nat Genet. 49 1052-161
[43]  
Bayless NL(2019)Transposable elements drive widespread expression of oncogenes in human cancers Nat Genet. 51 611-1152
[44]  
Wossidlo M(2014)Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance Nat Genet. 46 558-5184
[45]  
Wesche DJ(2020)Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia Nat Commun. 11 3506-110
[46]  
Fuentes DR(2008)Evolution of the mammalian transcription factor binding repertoire via transposable elements Genome Res. 18 1752-1556
[47]  
Swigut T(2021)TFs for TEs: the transcription factor repertoire of mammalian transposable elements Genes Dev. 35 22-15577
[48]  
Wysocka J(2012)Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors Genome Res. 22 1798-81
[49]  
Wang J(2015)The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses Genes Dev. 29 538-539
[50]  
Xie G(2018)Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses Genome Res. 28 1147-642
12345678910