The effect of duration of dependence and daily dose of tramadol in tramadol dependent patients on cognitive performance

被引：0

作者：

Ahmad H.E.K. ^{[1
,2
]}

Darweesh A.E.M. ^{[1
]}

Hassaan S.H.M. ^{[1
]}

Nooman M. ^{[1
]}

Shaaban I. ^{[3
]}

Sayed S.M. ^{[1
]}

机构：

[1] Assiut University Hospitals, Assiut

[2] Faculty of Medicine, Assiut University, Assiut

[3] Azhar University, Assiut

来源：

Middle East Current Psychiatry | / 26卷 / 1期

关键词：

BVMT-R; Cognition; IQ; MMSE; MoCA; P300 evoked potential; Tramadol;

D O I：

10.1186/s43045-019-0005-8

中图分类号：

学科分类号：

摘要：

Background: Tramadol dependence represents a major medical and legal hazardous phenomenon in the last decade. It is a synthetic opiate analgesic which exerts its therapeutic effect by its action on μ opioid receptors. It has a weak dependence ability. The present study investigated the effect of duration of dependence and daily dose of tramadol on cognitive performance. Cognitive functions were assessed using the following: the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA) test, Brief Visuospatial Memory Test–Revised (BVMT-R), Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), the P300 (ERP), and conventional electroencephalogram. Results: There was a non-significant negative correlation between the daily dose of tramadol and cognitive performance as regards IQ, Mini-Mental State Examination, MoCA score, P300 reaction time (μs), and deterioration index (r = − 0.08, P = 0.689; r = − 0.02, P = 0.896; r = − 0.11, P = 0.554; r = − 0.11, P = 0.581, r = − 0.17; P = 0.368, respectively). Additionally, the results showed non-significant negative correlation between the duration of dependence and the cognitive performance (r = − 0.19, P = 0.325; r = − 0.15, P = 0.424; r = − 0.30, P = 0.108; r = − 0.02, P = 0.909; r = − 0.02, P = 0.937, respectively). Conclusion: Daily dose and duration of tramadol dependence have a negative but non-significant effect on cognitive performance. © 2019, The Author(s).

引用

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