Thermal characterization of solid lipid nanoparticles containing praziquantel

被引:0
作者
Adelia Emilia de Almeida
Ana Luiza Ribeiro Souza
Douglas Lopes Cassimiro
Maria Palmira Daflon Gremião
Clóvis Augusto Ribeiro
Marisa Spirandeli Crespi
机构
[1] Universidade Estadual Paulista,Faculdade de Ciências Farmacêuticas, Departamento de Fármacos e Medicamentos
[2] Universidade Estadual Paulista,Departamento de Química Analítica
[3] Instituto de Química,undefined
来源
Journal of Thermal Analysis and Calorimetry | 2012年 / 108卷
关键词
Solid lipid nanoparticles; SLN; Kinetic compensation effects; Praziquantel; Nonisothermal kinetics;
D O I
暂无
中图分类号
学科分类号
摘要
Solid lipid nanoparticles (SLNs), loaded and unloaded with praziquantel (PRZ-load SLN and PRZ-unload SLN) were prepared by two different procedures: (a) oil-in-water hot microemulsion method, obtaining at 70 °C an optically transparent blend composed of surfactant, co-surfactant, and water; and (b) oil-in-water microemulsion method, dissolving the lipid in an immiscible organic solvent, emulsified in water containing surfactants and co-surfactant, and then evaporated under reduced pressure at 50 °C. The mean diameter, polydispersity index (PdI), and zeta potential were 187 to 665 nm, 0.300 to 0.655, and −25 to −28 mV respectively, depending on the preparation method. The components, binary mixture, SLNs loaded and unloaded with PRZ, and physical mixture were evaluated by differential scanning calorimetry (DSC) and thermogravimetry (TG). The non-isothermal isoconversional Flynn-Wall–Ozawa method was used to determine the kinetic parameters associated with the thermal decomposition of the samples. The experimental data indicated a linear relationship between the apparent activation energy E and the pre-exponential factor A, also called the kinetic compensation effect (KCE), allowing us to determine the stability with respect to the preparation method. Loading with PRZ increased the thermal stability of the SLNs.
引用
收藏
页码:333 / 339
页数:6
相关论文
共 88 条
[1]  
Jeziorski MC(2006)Voltage-gated calcium channel subunits from platyhelminths: potential role in praziquantel action Int J Parasitol. 36 625-632
[2]  
Greenberg RM(2006)Evaluation of melt granulation and ultrasonic spray congealing as techniques to enhance the dissolution of praziquantel Int J Pharm. 318 92-102
[3]  
Passerini N(2008)Nimodipine loaded lipid nanospheres prepared by solvent diffusion method in a drug saturated aqueous system Int J Pharm. 348 146-152
[4]  
Albertici B(2008)Cyclosporine-loaded solid lipid nanoparticles (SLN Eur J Pharm Biopharm. 68 535-544
[5]  
Perissuti B(2008)): Drug–lipid physicochemical interactions and characterization of drug incorporation Int J Pharm. 346 124-132
[6]  
Rodriguez L(2010)Nanostructured lipid carrier (NLC) based gel of celecoxib Pharm Res 27 1469-1486
[7]  
Hu FQ(2003)Phospholipids and lipid-based formulations in oral drug delivery Int J Pharm. 256 133-140
[8]  
Zhang Y(2007)Interactions of solid lipid nanoparticles with membranes and leukocytes studied by EPR Int J Pharm. 335 167-175
[9]  
Du YZ(2007)Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics Colloids and Surf A. 311 106-111
[10]  
Yuan H(2000)Preparation and characterization of monocaprate nanostructured lipid carriers Eur J Pharm Biopharm. 50 161-177