The study of telomerase activity in gastric cancer

被引：3

作者：

Svinareva L.V. ^{[1
,2
]}

Glukhov A.I. ^{[2
,3
]}

Zimnik O.V. ^{[1
]}

Bykov I.I. ^{[3
]}

Khorobrykh T.V. ^{[3
]}

Shvets V.I. ^{[2
]}

机构：

[1] Moscow Scientific Research Institute of Medical Ecology, Moscow, 117149

[2] M.V. Lomonosov Moscow State Academy of Fine Chemical Technology, Moscow

[3] I.M. Sechenov Moscow Medical Academy, Moscow

来源：

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | 2011年 / 5卷 / 2期

关键词：

Carcinogenesis; Gastric adenocarcinoma; Telomerase; Telomerase activity (ta);

D O I：

10.1134/S1990750811020168

中图分类号：

学科分类号：

摘要：

Telomerase activity was examined in tissue specimens from patients with gastric adenocarcinomas and gastric lymphoma using a modified TRAP (telomeric repeat amplification protocol) assay. Telomerase activity was found in 16 of 18 (89%) patients with gastric adenocarcinomas and gastric lymphoma, whereas it was not detected in a patient with noncancerous gastric mucosa. Almost all analyzed specimens had "high" and "very high" levels of telomerase activity. Telomerase is almost certainly associated with the process of malignant transformation and it can be an important marker for diagnostics of gastric cancer. © Pleiades Publishing, Ltd., 2011.

引用

页码：188 / 192

页数：4

共 10 条

[1]

Yokozaki H., Yasui W., Tahara E., Int. Rev. Cytol., 204, pp. 49-65, (2001)

[2]

Layke J.C., Lopez P.P., Amer. Family Physician, 69, pp. 1136-1139, (2004)

[3]

Shay J.W., Bacchetti S., Eur. J. Cancer, 5, pp. 787-789, (1997)

[4]

Greider C.W., Blackburn E.H., Scientific American, 274, pp. 92-97, (1996)

[5]

Shay J.W., Wright W.E., Curr. Opin. Oncol., 8, pp. 66-71, (1996)

[6]

Mao L., Elnaggar A.K., Fan Y.H., Lee J.S., Lippman S.M., Kayser S., Lotan R., Hong W.K., Cancer Res., 56, pp. 5600-5604, (1996)

[7]

Zhan W., Ma J., Peng J., Gao J., Cai S., Wang J., Zheng Z., Wang L., World J. Gastroenterol., 5, pp. 316-319, (1999)

[8]

Bradford M., Anal. Biochem., 72, pp. 248-254, (1976)

[9]

Kim N.W., Piatyszek M.A., Prowse K.R., Science, 266, pp. 2011-2015, (1994)

[10]

Glukhov A.I., Zimnik O.V., Gordeev S.A., Severin S.E., Biochem. Biophys. Res. Comm., L248, pp. 368-371, (1998)

← 1 →