Olfactory behavior and physiology are disrupted in prion protein knockout mice

被引：0

作者：

Claire E Le Pichon

Matthew T Valley

Magdalini Polymenidou

Alexander T Chesler

Botir T Sagdullaev

Adriano Aguzzi

Stuart Firestein

机构：

[1] Columbia University,Department of Biological Sciences

[2] Institute of Neuropathology,undefined

[3] University Hospital Zürich,undefined

[4] Present addresses: Ludwig Institute for Cancer Research,undefined

[5] University of California at San Diego,undefined

[6] 9500 Gilman Drive,undefined

[7] La Jolla,undefined

[8] California 92093,undefined

[9] USA (M.P.) and Weill Medical College of Cornell University,undefined

[10] 785 Mamaroneck Avenue,undefined

[11] White Plains,undefined

[12] New York 10605,undefined

[13] USA (B.T.S.).,undefined

来源：

Nature Neuroscience | 2009年 / 12卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The normal physiological function of the prion protein PrPC remains unknown. Here, the authors report that PrP knockout mice show altered behavior in two olfactory tasks and that PrP deficiency affects oscillatory activity in the olfactory bulb. Both the behavioral and electrophysiological phenotypes could be rescued by transgenic neuronal-specific expression of PrPC.

引用

页码：60 / 69

页数：9

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