Synthesis and antitumor evaluation of novel sulfonylcycloureas derived from nitrogen mustard

被引：0
作者：
H. Cheloufi
B. Belhani
T. S. Ouk
R. Zerrouki
N.-E. Aouf
M. Berredjem
机构：
[1] Annaba University,Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Badji
[2] Université de Limoges,Mokhtar
来源：
Molecular Diversity | 2016年 / 20卷
关键词：
Cancer; Sulfonamides; Nitrogen mustard; Sulfonylcycloureas; Antitumor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new series of sulfonylcycloureas derivatives have been synthesized and evaluated in vitro for their antitumor activity against four cancer cell lines (A431, Jurkat, U266, and K562). These compounds were prepared by the condensation of several sulfonamides (2a–m) with ethyl bis(2-chloroethyl)carbamate (1a). The relative cytotoxicity of these new derivatives in comparison to chlorambucil is reported.
引用
收藏
页码：399 / 405
页数：6
相关论文
共 184 条
[1]  
Eckhardt S(2002)Recent progress in the development of anticancer agents Curr Med Chem-Anti-Cancer Agents 2 419-439
[2]  
Kapuriya N(2011)Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents Bioorg Med Chem 19 471-485
[3]  
Kakadiya R(2006)On the role of stereo-electronic effects in tuning the selectivity and rate of DNA alkylation by duocarmycins Org Biomol Chem 4 1242-1251
[4]  
Dong H(2010)Synthesis and biological evaluation of cyclic nitrogen mustards based on carnitine framework Eur J Med Chem 45 4140-4148
[5]  
Kumar A(2012)Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation Org Biomol Chem 10 6850-6860
[6]  
Lee PC(2013)Designing and synthesis of novel quinazoline nitrogen mustard derivatives as potential therapeutic agents for cancer Eur J Med Chem 67 293-301
[7]  
Zhang X(2012)Cytogenetic and antineoplastic effects by newly synthesised steroidal alkylators in lymphocytic leukaemia P388 cells in vivo Mutat Res 746 1-6
[8]  
Chou TC(2011)Bivalent bendamustine and melphalan derivatives as anticancer agents Eur J Med Chem 46 1604-1615
[9]  
Lee TC(1990)Novel agents effective against solid tumors: the diaryl sulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships J Med Chem 33 2393-2407
[10]  
Chen CH(2014)Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity Bioorg Med Chem 22 2643-2647
12345678910