The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo

被引：0
作者：
S. de Frutos
M. Griera
M. Hatem-Vaquero
S. Campillo
E. Gutiérrez-Calabres
D. García-Ayuso
M. Pardo
L. Calleros
M. Rodríguez-Puyol
D. Rodríguez-Puyol
机构：
[1] Unidad Fisiología,Departamento de Biología de Sistemas
[2] Facultad de Medicina,undefined
[3] Universidad de Alcalá,undefined
[4] Instituto Ramon Y Cajal de Investigación Sanitaria,undefined
[5] Fundación Renal Iñigo Álvarez de Toledo and RedInRen from Instituto de Salud Carlos III,undefined
[6] and NOVELREN from Comunidad de Madrid,undefined
[7] Graphenano Medical Care S.L.,undefined
[8] Biomedical Research Foundation from Hospital Universitario Príncipe de Asturias,undefined
[9] Instituto de Investigación Sanitaria de Santiago,undefined
[10] Servizo Galego de Saúde,undefined
[11] Nephrology Unit from Hospital Príncipe de Asturias and Department of Medicine from Universidad de Alcalá,undefined
来源：
Cell & Bioscience | / 12卷
关键词：
Tirofiban; Integrin-beta1; Integrin-linked kinase; AKT; Adipogenesis; Obesity; Hypertrophic adipocyte; Browning; White adipose tissue; Lipolysis; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 410 条
  • [1] O'Rourke RW(2018)Adipose tissue and the physiologic underpinnings of metabolic disease Surg Obes Relat Dis 14 1755-1763
  • [2] Ali AT(2013)Adipocyte and adipogenesis Eur J Cell Biol 92 229-236
  • [3] Hochfeld WE(2000)The fatty acid transport function of fatty acid-binding proteins Biochim Biophys Acta 1486 28-44
  • [4] Myburgh R(2006)Adipose triglyceride lipase and hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism J Biol Chem 281 40236-40241
  • [5] Pepper MS(2016)Microenvironmental control of adipocyte fate and function Trends Cell Biol 26 745-755
  • [6] Storch J(2014)Distinction of white, beige and brown adipocytes derived from mesenchymal stem cells World J Stem Cells 6 33-42
  • [7] Thumser AE(2020)Sea buckthorn ( Food Sci Biotechnol 29 1511-1518
  • [8] Schweiger M(2013) L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells Nat Med 19 1252-1263
  • [9] Schreiber R(2015)Brown and beige fat: development, function and therapeutic potential Front Endocrinol (Lausanne) 20 164-1203
  • [10] Haemmerle G(2013)Bioengineering beige adipose tissue therapeutics Cell Rep 5 1196-1049
12345678910