Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

被引：0
作者：
Meaghan Morris
Giselle M Knudsen
Sumihiro Maeda
Jonathan C Trinidad
Alexandra Ioanoviciu
Alma L Burlingame
Lennart Mucke
机构：
[1] Gladstone Institute of Neurological Disease,Department of Biological Chemistry
[2] Biochemistry,Department of Pharmaceutical Chemistry
[3] Cellular and Molecular Biology Graduate Program,Department of Neurology
[4] The Johns Hopkins University School of Medicine,undefined
[5] Mass Spectrometry Facility,undefined
[6] University of California,undefined
[7] University of California,undefined
[8] Present address: Department of Chemistry,undefined
[9] Indiana University,undefined
[10] Bloomington,undefined
[11] Indiana,undefined
[12] USA.,undefined
来源：
Nature Neuroscience | 2015年 / 18卷
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摘要：
Abnormal post-translational modifications of tau may contribute to Alzheimer's disease, but normal tau modifications are poorly understood. Using advanced mass spectrometry, a great variety of modifications were identified on endogenous mouse tau. Tau appears to be highly regulated and may fulfill diverse functions, most of which remain to be defined.
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页码：1183 / 1189
页数：6
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