FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake

被引:0
作者
Shikshya Shrestha
Woohyun Cho
Benjamin Stump
Jewel Imani
Anthony M. Lamattina
Pierce H. Louis
James Pazzanese
Ivan O. Rosas
Gary Visner
Mark A. Perrella
Souheil El-Chemaly
机构
[1] Brigham and Women’s Hospital,Division of Pulmonary and Critical Care Medicine
[2] Harvard Medical School,Present Address: Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine
[3] Pusan National University Yangsan Hospital,Deparmtent of Pediatrics
[4] Boston Children Hospital,undefined
[5] Harvard Medical School,undefined
来源
Molecular Medicine | 2020年 / 26卷
关键词
Lung lymphatic; Endothelial cells; LYVE-1; TERT; Senescence; Fk506; Hyaluronan;
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  • [1] Aix E(2016)Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation J Cell Biol 213 571-583
  • [2] Gutierrez-Gutierrez O(2011)The lymphatic vasculature in disease Nat Med 17 1371-1380
  • [3] Sanchez-Ferrer C(2009)TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice J Clin Invest 119 2954-2964
  • [4] Aguado T(2018)TGFbeta counteracts LYVE-1-mediated induction of lymphangiogenesis by small hyaluronan oligosaccharides J Mol Med (Berl) 96 199-209
  • [5] Flores I(2016)Markers of cellular senescence. Telomere shortening as a marker of cellular senescence Aging (Albany NY) 8 3-11
  • [6] Alitalo K(2003)Post-transplant bronchiolitis obliterans Eur Respir J 22 1007-1018
  • [7] Baluk P(2012)Contribution: angiogenesis analyzer ImageJ News 5 2012-1059
  • [8] Yao LC(2017)The registry of the International Society for Heart and Lung Transplantation: thirty-fourth adult lung and heart-lung transplantation Report-2017; focus theme: allograft ischemic time J Heart Lung Transplant 36 1047-35734
  • [9] Feng J(2009)Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells J Biol Chem 284 35725-425
  • [10] Romano T(2002)Human telomerase and its regulation Microbiol Mol Biol Rev 66 407-19952