2-Acylmethyl-1H-benzimidazoles in the Biginelli reaction

被引：0

作者：

Dzvinchuk, I.B. ^{[1
]}

Makitruk, T.V. ^{[1
]}

Lozinskii, M.O. ^{[1
]}

机构：

[1] Institute of Organic Chemistry, Natl. Academy of Sciences of Ukraine

来源：

Chemistry of Heterocyclic Compounds | 2003年 / 39卷 / 04期

关键词：

Aldehydes; Benzimidazoles; Biginelli reaction; Cyclocondensation; Pyrimidines; Ureas;

D O I：

10.1023/A:1024757128442

中图分类号：

学科分类号：

摘要：

By cyclocondensation of 2-acylmethyl-1H-benzimidazoles with aromatic aldehydes and urea according to the Biginelli reaction, we have obtained previously unknown 6-substituted 4-aryl-5-(2-benzimidazolyl-2-oxo-1,2,3,4-tetrahydropyrimidines. We have developed an efficient procedure for conducting the three-component reaction at fairly low temperatures. We have analyzed the structural features of the synthesized compounds. based on 1H NMR spectra and IR spectroscopy.

引用

页码：455 / 460

页数：5

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