2-Acylmethyl-1H-benzimidazoles in the Biginelli reaction

被引：0
作者：
Dzvinchuk, I.B. [1 ]
Makitruk, T.V. [1 ]
Lozinskii, M.O. [1 ]
机构：
[1] Institute of Organic Chemistry, Natl. Academy of Sciences of Ukraine
来源：
Chemistry of Heterocyclic Compounds | 2003年 / 39卷 / 04期
关键词：
Aldehydes; Benzimidazoles; Biginelli reaction; Cyclocondensation; Pyrimidines; Ureas;
D O I：
10.1023/A:1024757128442
中图分类号：
学科分类号：
摘要：
By cyclocondensation of 2-acylmethyl-1H-benzimidazoles with aromatic aldehydes and urea according to the Biginelli reaction, we have obtained previously unknown 6-substituted 4-aryl-5-(2-benzimidazolyl-2-oxo-1,2,3,4-tetrahydropyrimidines. We have developed an efficient procedure for conducting the three-component reaction at fairly low temperatures. We have analyzed the structural features of the synthesized compounds. based on 1H NMR spectra and IR spectroscopy.
引用
收藏
页码：455 / 460
页数：5
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