An overview on neurobiology and therapeutics of attention-deficit/hyperactivity disorder

被引：36

作者：

da Silva, Bruna Santos ^{[1
,2
,3
,6
,7
]}

Grevet, Eugenio Horacio ^{[1
,4
,5
]}

Silva, Luiza Carolina Fagundes ^{[1
,4
,5
]}

Ramos, Joao Kleber Neves ^{[6
,7
]}

Rovaris, Diego Luiz ^{[6
,7
]}

Bau, Claiton Henrique Dotto ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Fed Rio Grande Do Sul, Hosp Clin Porto Alegre, ADHD & Dev Psychiat Programs, Porto Alegre, Brazil

[2] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, Brazil

[3] Univ Fed Rio Grande do Sul, Inst Biociencias, Grad Program Genet & Mol Biol, Porto Alegre, Brazil

[4] Univ Fed Rio Grande, Dept Psychiat, Grad Program Psychiat & Behav Sci, Porto Alegre, Brazil

[5] Univ Fed Rio Grande do Sul, Fac Med, Grad Program Psychiat & Behav Sci, Porto Alegre, Brazil

[6] Univ Sao Paulo, Inst Ciencias Biomed, Dept Physiol & Biophys, Sao Paulo, Brazil

[7] Univ Sao Paulo, Inst Ciencias Biomed, PhysioGen Lab, Lab Physiol Genom Mental Hlth, Sao Paulo, Brazil

来源：

DISCOVER MENTAL HEALTH | 2023年 / 3卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

DEFICIT HYPERACTIVITY DISORDER; SERIOUS CARDIOVASCULAR EVENTS; GENOME-WIDE ASSOCIATION; ADHD MEDICATIONS; ADULT ADHD; PHARMACOLOGICAL MANAGEMENT; DNA METHYLATION; YOUNG ADULTHOOD; LIFE-SPAN; METAANALYSIS;

D O I：

10.1007/s44192-022-00030-1

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition characterized by developmentally inappropriate symptoms of inattention and/or hyperactivity/impulsivity, which leads to impairments in the social, academic, and professional contexts. ADHD diagnosis relies solely on clinical assessment based on symptom evaluation and is sometimes challenging due to the substantial heterogeneity of the disorder in terms of clinical and pathophysiological aspects. Despite the difficulties imposed by the high complexity of ADHD etiology, the growing body of research and technological advances provide good perspectives for understanding the neurobiology of the disorder. Such knowledge is essential to refining diagnosis and identifying new therapeutic options to optimize treatment outcomes and associated impairments, leading to improvements in all domains of patient care. This review is intended to be an updated outline that addresses the etiological and neurobiological aspects of ADHD and its treatment, considering the impact of the "omics" era on disentangling the multifactorial architecture of ADHD.

引用

页数：21

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