Comparison of the efficacy of 177Lu-EDTMP, 177Lu-DOTMP and 188Re-HEDP towards bone osteosarcoma: an in vitro study

被引：0
作者：
Chandan Kumar
Rohit Sharma
Kusum Vats
Madhav B. Mallia
Tapas Das
H. D. Sarma
Ashutosh Dash
机构：
[1] Bhabha Atomic Research Centre,Radiopharmaceuticals Division
[2] Bhabha Atomic Research Centre,Radiation Biology and Health Sciences Division
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2019年 / 319卷
关键词：
Lu-EDTMP, ; Lu-DOTMP, ; Re-HEDP; G2/M arrest; Apoptosis; Osteosarcoma; Cell toxicity;
D O I：
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中图分类号：
学科分类号：
摘要：
Among the radiopharmaceuticals harnessed for palliation of bone pain in osseous metastases patients, 177Lu labeled phosphonates such as EDTMP (Ethylene diamine tetramethylene phosphonic acid) as well as DOTMP (1,4,7,10-tetraaza-cyclo-dodecane-1,4,7,10 tetraethylene phosphonic acid) and 188Re-labeled HEDP (1,1-hydroxyethylene diphosphonic acid) seem to be the most favorable for treatment of small and medium/large size bone lesions, respectively. A comparative assessment of 177Lu-EDTMP, 177Lu-DOTMP and 188Re-HEDP in osteosarcoma tumor cell line was carried out to evaluate their relative efficacy. It was found that 188Re-HEDP is more potent in induction of cell toxicity and apoptosis compared to the 177Lu-EDTMP and 177Lu-DOTMP, thus 188Re-HEDP might have great clinical significance.
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页码：51 / 59
页数：8
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