Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial

被引：0

作者：

Antoine Roquilly

Bruno Francois

Olivier Huet

Yoann Launey

Sigismond Lasocki

Emmanuel Weiss

Melanie Petrier

Yannick Hourmant

Marwan Bouras

Karim Lakhal

Cecilia Le Bel

Delphine Flattres Duchaussoy

Laia Fernández-Barat

Adrian Ceccato

Laurent Flet

Alexandra Jobert

Jeremie Poschmann

Veronique Sebille

Fanny Feuillet

Despoina Koulenti

Antoni Torres

机构：

[1] Nantes Université,ICU Department and Inserm CIC 1435 & UMR 1092

[2] CHU Nantes,Département d’anesthésie réanimation et medecine peri

[3] INSERM,operatoire, CHRU de Brest

[4] Anesthesie Réanimation,Department of Anaesthesia, Critical Care and Perioperative Medicine

[5] CIC 1413,Department of Anesthesiology and Critical Care Medicine

[6] Nantes Université,Department of Anesthesiology and Critical Care

[7] CHU Nantes,2nd Critical Care Department

[8] INSERM,Faculty of Medicine, UQ Centre for Clinical Research

[9] Center for Research in Transplantation and Translational Immunology,undefined

[10] UMR 1064,undefined

[11] University Hospital of Limoges,undefined

[12] Université de Bretagne Occidentale,undefined

[13] Univ Rennes,undefined

[14] CHU Rennes,undefined

[15] University Hospital of Angers,undefined

[16] Université Paris Cité,undefined

[17] INSERM UMR_S1149,undefined

[18] and AP-HP Nord,undefined

[19] Hôpital Beaujon,undefined

[20] CELLEX research laboratories,undefined

[21] CibeRes (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias,undefined

[22] 06/06/0028),undefined

[23] Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS),undefined

[24] Servei de Pneumologia,undefined

[25] Hospital Clinic,undefined

[26] Barcelona,undefined

[27] Universitat de Barcelona,undefined

[28] CIBERES,undefined

[29] Icrea,undefined

[30] IDIBAPS,undefined

[31] Nantes Université,undefined

[32] CHU Nantes,undefined

[33] Pharmacie,undefined

[34] Nantes Université,undefined

[35] CHU Nantes,undefined

[36] DRI,undefined

[37] Département promotion,undefined

[38] cellule vigilances recherche,undefined

[39] Nantes Université,undefined

[40] CHU Nantes,undefined

[41] DRI,undefined

[42] Plateforme de Méthodologie et de Biostatistique,undefined

[43] Nantes Université,undefined

[44] Université de Tours,undefined

[45] CHU Nantes,undefined

[46] CHU Tours,undefined

[47] INSERM,undefined

[48] SPHERE U1246,undefined

[49] Attikon University Hospital,undefined

[50] The University of Queensland,undefined

来源：

Intensive Care Medicine | 2023年 / 49卷

关键词：

Intensive care; Hospital-acquired pneumonia; Interferon-gamma; Immunotherapy; Immunosuppression;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

页码：530 / 544

页数：14

共 24 条

[1] Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trial
Roquilly, Antoine
Francois, Bruno
Huet, Olivier
Launey, Yoann
Lasocki, Sigismond
Weiss, Emmanuel
Petrier, Melanie
Hourmant, Yannick
Bouras, Marwan
Lakhal, Karim
Le Bel, Cecilia
Duchaussoy, Delphine Flattres
Fernandez-Barat, Laia
Ceccato, Adrian
Flet, Laurent
Jobert, Alexandra
Poschmann, Jeremie
Sebille, Veronique
Feuillet, Fanny
Koulenti, Despoina
Torres, Antoni
INTENSIVE CARE MEDICINE, 2023, 49 (05) : 530 - 544
[2] Hospital-acquired bacterial pneumonia in critically ill patients: from research to clinical practice
Kouroupis, Pompeo Costantino
O'Rourke, Niall
Kelly, Sinead
McKittrick, Myles
Noppe, Elne
Reyes, Luis F.
Rodriguez, Alejandro
Martin-Loeches, Ignacio
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2024, 22 (06) : 423 - 433
[3] Effect of synbiotic therapy on the incidence of ventilator associated pneumonia in critically ill patients: a randomised, double-blind, placebo-controlled trial
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Gardiner, Dale
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Snape, Susan E.
Weston, Vivienne C.
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Girling, Keith J.
INTENSIVE CARE MEDICINE, 2009, 35 (05) : 854 - 861
[4] Effect of synbiotic therapy on the incidence of ventilator associated pneumonia in critically ill patients: a randomised, double-blind, placebo-controlled trial
David J. W. Knight
Dale Gardiner
Amanda Banks
Susan E. Snape
Vivienne C. Weston
Stig Bengmark
Keith J. Girling
Intensive Care Medicine, 2009, 35
[5] Correction of vitamin D deficiency in critically ill patients - VITdAL@ICU study protocol of a double-blind, placebo-controlled randomized clinical trial
Amrein, Karin
Schnedl, Christian
Berghold, Andrea
Pieber, Thomas R.
Dobnig, Harald
BMC ENDOCRINE DISORDERS, 2012, 12
[6] Correction of vitamin D deficiency in critically ill patients - VITdAL@ICU study protocol of a double-blind, placebo-controlled randomized clinical trial
Karin Amrein
Christian Schnedl
Andrea Berghold
Thomas R Pieber
Harald Dobnig
BMC Endocrine Disorders, 12
[7] Metabolic inefficacy of a short-term low-dose insulin regimen in critically ill patients: a randomized, placebo-controlled trial
Ulrike Holzinger
Alexandra Zauner
Petra Nimmerrichter
Mark Schiefermeier
Klaus Ratheiser
Christian Zauner
Wiener klinische Wochenschrift, 2004, 116 : 603 - 607
[8] Metabolic inefficacy of a short-term low-dose insulin regimen in critically ill patients: a randomized, placebo-controlled trial
Holzinger, U
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[9] Clinical evaluation of the BioFire Respiratory Pathogen Panel for the guidance of empirical antimicrobial therapy in critically ill patients with hospital-acquired pneumonia: A multicenter, quality improvement project
Poulain, Cecile
Launey, Yoann
Bouras, Marwan
Lakhal, Karim
Dargelos, Laura
Cremet, Lise
Gibaud, Sophie-Anne
Corvec, Stephane
Seguin, Philippe
Rozec, Bertrand
Asehnoune, Karim
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ANAESTHESIA CRITICAL CARE & PAIN MEDICINE, 2024, 43 (02)
[10] Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients - A multicenter, randomized, double-blind placebo-controlled trial
Bleichner, G
Blehaut, H
Mentec, H
Moyse, D
INTENSIVE CARE MEDICINE, 1997, 23 (05) : 517 - 523

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