Two New Antibacterial Isoindolin-1-Ones from the Leaves of Cigar Tobacco

Two new isoindolin-1-ones, tobindoles E and F (1 and 2), were isolated from the leaves of cigar tobacco (a variety of Nicotiana tabacum). Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their antibacterial activity. The results showed that both compounds exhibited high antibacterial activity against the 11 microbial strains isolated from the oral saliva of smokers.