Ozone: A New Therapeutic Agent in Vascular Diseases

被引:0
|
作者
Velio Bocci
Iacopo Zanardi
Valter Travagli
机构
[1] University of Siena,Department of Physiology
[2] University of Siena,Department of Pharmaceutical Chemistry and Technology
来源
American Journal of Cardiovascular Drugs | 2011年 / 11卷
关键词
Ozone; Chronic Heart Failure; Peripheral Arterial Disease; Ozone Concentration; Carnosine;
D O I
暂无
中图分类号
学科分类号
摘要
In this article, we scientifically evaluate the bio-oxidative procedure known as oxygen-ozone therapy. Research over a decade has established a comprehensive framework for understanding and recommending this type of autohemotherapy in vascular diseases. In contrast, a non-specific immunomodulation therapy, using heavily oxidized and denatured blood, has been recently used in studies involving a total of approximately 3000 patients and has led to ‘disappointing’ results. Such a treatment appears to be an inappropriate example of the so-called minor autohemotherapy, and its poor outcomes may discourage any further studies. Therefore it appears necessary to clarify that the use of only a minimal ozone dose and a valid experimental protocol is likely to produce beneficial results. Millions of people suffer from chronic limb, brain, and heart ischemia, and such patients may benefit if appropriate ozone therapy could be implemented. Accordingly, we propose the need for a well designed, multicenter, clinical trial to be conducted.
引用
收藏
页码:73 / 82
页数:9
相关论文
共 50 条
  • [1] Ozone: A New Therapeutic Agent in Vascular Diseases
    Bocci, Veils
    Zanardi, Iacop
    Travagli, Vatter
    AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2011, 11 (02) : 73 - 82
  • [2] Myocardin New Therapeutic Agent in Vascular Disease?
    Long, Xiaochun
    Miano, Joseph M.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (10) : 2284 - 2285
  • [3] Hydrogen sulfide: A new therapeutic target in vascular diseases
    Zhu, Cuilin
    Liu, Qing
    Li, Xin
    Wei, Ran
    Ge, Tongtong
    Zheng, Xiufen
    Li, Bingjin
    Liu, Kexiang
    Cui, Ranji
    FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [5] Mithramycin, an Agent for Developing New Therapeutic Drugs for Neurodegenerative Diseases
    Osada, Nobuhiro
    Kosuge, Yasuhiro
    Ishige, Kumiko
    Ito, Yoshihisa
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, 122 (04) : 251 - 256
  • [6] ATP Citrate Lyase a New Therapeutic Target for Vascular Remodeling Diseases
    Grobs, Yann
    Lemay, Sarah-eve
    Romanet, Charlotte
    Bonnet, Sandra Breuils
    Orcholski, Mark
    Bourgeois, Alice
    Sauvaget, Melanie
    Shimauchi, Kana
    Voisine, Pierre
    Paulin, Roxane
    Potus, Francois
    Provencher, Steeve
    Boucherat, Olivier
    Bonnet, Sebastien
    CIRCULATION, 2021, 144
  • [7] BLOOD AND BLOOD-VESSELS - A NEW THERAPEUTIC APPROACH TO VASCULAR DISEASES
    BOISSEAU, MR
    ATTALI, JR
    JOUVE, R
    KAPTUE, M
    LAGRUE, G
    MARTIN, P
    SEMAINE DES HOPITAUX, 1985, 61 (35-3): : 2593 - 2595
  • [8] TAURINE AS A THERAPEUTIC AGENT IN VASCULAR PAIN
    SICUTERI, F
    FANCIULL.M
    FRANCHI, G
    GIOTTI, A
    GUIDOTTI, A
    CLINICAL MEDICINE, 1970, 77 (05) : 21 - &
  • [9] Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases
    Sun, Albert Y.
    Wang, Qun
    Simonyi, Agnes
    Sun, Grace Y.
    MOLECULAR NEUROBIOLOGY, 2010, 41 (2-3) : 375 - 383
  • [10] Resveratrol as a Therapeutic Agent for Neurodegenerative Diseases
    Albert Y. Sun
    Qun Wang
    Agnes Simonyi
    Grace Y. Sun
    Molecular Neurobiology, 2010, 41 : 375 - 383