Single-molecule force spectroscopy: Optical tweezers, magnetic tweezers and atomic force microscopy

被引：0
|
作者：
Neuman K.C. [1 ]
Nagy A. [1 ]
机构：
[1] Laboratory of Molecular Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
来源：
Nature Methods | 2008年 / 5卷 / 6期
关键词：
D O I：
10.1038/nmeth.1218
中图分类号：
学科分类号：
摘要：
Single-molecule force spectroscopy has emerged as a powerful tool to investigate the forces and motions associated with biological molecules and enzymatic activity. The most common force spectroscopy techniques are optical tweezers, magnetic tweezers and atomic force microscopy. Here we describe these techniques and illustrate them with examples highlighting current capabilities and limitations.
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页码：491 / 505
页数：14
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