Efalizumab Therapy for Psoriasis in Patients with Inadequate Responses to Etanercept

被引：0

作者：

Jesse M. Kramer

James E. Turner

机构：

[1] Mercy Medical Group,Dermatology Division

[2] Mid-South Dermatology and Skin Cancer Center,undefined

来源：

American Journal of Clinical Dermatology | 2009年 / 10卷

关键词：

Psoriasis; Etanercept; Body Surface Area; Psoriatic Arthritis; Inadequate Response;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Efalizumab is a recombinant humanized monoclonal antibody approved for the treatment of adult patients with moderate-to-severe chronic plaque psoriasis. We present six cases of favorable response to efalizumab therapy in patients with psoriasis who demonstrated inadequate response or who were nonresponders to treatment with etanercept, a tumor necrosis factor-α-binding fusion protein. The subsequent response of these patients suggests that efalizumab may be a viable treatment option for patients with psoriasis who respond poorly to etanercept.

引用

页码：134 / 140

页数：6

共 17 条

[1]

Krueger GG(2004)Current concepts and review of alefacept in the treatment of psoriasis Dermatol Clin 22 407-26

[2]

Papp KA(2005)A global phase III randomized controlled trial of etanercept in psoriasis: safety, efficacy, and effect of dose reduction Br J Dermatol 152 1304-12

[3]

Tyring S(2005)Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, doubleblind trial Lancet 366 1367-74

[4]

Lahfa M(2006)A 96-week phase III study of safety and efficacy of etanercept 50mg twice weekly in patients with psoriasis [abstract] J Am Acad Dermatol 54 10-80

[5]

Reich K(2003)Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial JAMA 290 3073-5

[6]

Nestle FO(2000)Two considerations for patients with psoriasis and their clinicians: what defines mild, moderate, and severe psoriasis? What constitutes a clinically significant improvement when treating psoriasis J Am Acad Dermatol 43 281-7

[7]

Papp K(2005)Current severe psoriasis and the rule of tens Br J Dermatol 152 861-undefined

[8]

Tyring S(undefined)undefined undefined undefined undefined-undefined

[9]

Poulin Y(undefined)undefined undefined undefined undefined-undefined

[10]

Langley R(undefined)undefined undefined undefined undefined-undefined

← 1 2 →