Genomic imprinting and assisted reproduction

被引：33
作者：
Paoloni-Giacobino A. [1 ]
Chaillet J.R. [1 ]
机构：
[1] Dept. of Molec. Genet. and Biochem., University of Pittsburgh, W1007 Biomedical Science Tower, Pittsburgh, PA 15213
来源：
Reproductive Health | / 1卷 / 1期
关键词：
Imprint Gene; Assisted Reproduction; Primordial Germ Cell; Intracytoplasmic Sperm Injection; Angelman Syndrome;
D O I：
10.1186/1742-4755-1-6
中图分类号：
学科分类号：
摘要：
Imprinted genes exhibit a parent-of-origin specific pattern of expression. Such genes have been shown to be targets of molecular defects in particular genetic syndromes such as Beckwith-Wiedemann and Angelman syndromes. Recent reports have raised concern about the possibility that assisted reproduction techniques, such as in vitro fertilization or intracytoplasmic sperm injection, might cause genomic imprinting disorders. The number of reported cases of those disorders is still too small to draw firm conclusions and the safety of these widely used assisted reproduction techniques needs to be further evaluated. © 2004 Paoloni-Giacobino and Chaillet; licensee BioMed Central Ltd.
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