CD133: A stem cell biomarker and beyond

被引：236
作者：
Li Z. [1 ,2 ]
机构：
[1] Central Laboratory, 10th People's Hospital, Tongji University, Shanghai 200072
[2] Eastern Hepatobiliary Surgery Hospital/Institute, Second Military Medical University, Shanghai 200438
来源：
Experimental Hematology & Oncology | / 2卷 / 1期
基金：
中国国家自然科学基金;
关键词：
CD133 Expression; Cancer Stem Cell; Primary Cilium; Gallbladder Carcinoma; Malignant Peripheral Nerve Sheath Tumor;
D O I：
10.1186/2162-3619-2-17
中图分类号：
学科分类号：
摘要：
Cancer stem cells (CSCs) or tumor initiating cells (TICs) contribute to tumorigenesis, metastasis, recurrence and chemoresistance. CD133, a pentaspan membrane glycoprotein, has been used as a stem cell biomarker for isolation of stem-like cells from a variety of normal and pathological tissues as well as cell lines since its discovery in 1999. Recent studies are focusing on the functionality of CD133. In this review, we summarize new insights into CD133 regulation and the involvement of CD133 in cell self-renewal, tumorigenesis, metastasis, resistance, metabolism, differentiation, autophagy, apoptosis, and regeneration. © 2013 Li; licensee BioMed Central Ltd.
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