Coexistence of lung cancer and immunoglobulin G4-related lung disease in a nodule: A case report

被引：8

作者：

Tashiro H. ^{[1
]}

Takahashi K. ^{[1
]}

Nakamura T. ^{[1
]}

Komiya K. ^{[1
]}

Kimura S. ^{[1
]}

Sueoka-Aragane N. ^{[1
]}

机构：

[1] Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga

来源：

Journal of Medical Case Reports | / 10卷 / 1期

关键词：

IgG4-related disease; Lung cancer; Lung nodule;

D O I：

10.1186/s13256-016-0898-3

中图分类号：

学科分类号：

摘要：

Background: Immunoglobulin G4-related disease is characterized by infiltration of immunoglobulin G4-positive plasmacytes in various organs. The radiological findings of lung involvement of immunoglobulin G4-related disease include hilar and mediastinal lymphadenopathies, thickness of bronchovascular bundles, peribronchovascular consolidation, and lung nodules. Although a pathological approach is needed to diagnose immunoglobulin G4-related disease, it is ordinarily diagnosed by biopsy from one lesion even if there are multiple lesions. We reported a rare case of the coexistence of immunoglobulin G4-related disease and lung cancer in the same lung nodule. Case presentation: A 72-year-old Japanese man visited our hospital for evaluation of a nodular shadow in the middle lobe of his right lung that was seen on chest radiograph and computed tomography scan. An abdominal computed tomography scan showed a tumefactive lesion in his anterior sacral spine. Blood examinations revealed high serum immunoglobulin G4 concentration at 346 mg/dl, renal dysfunction, and anemia. He underwent right upper lobectomy and regional lymph node dissection. Pathologic findings of the lung nodule showed lepidic pattern adenocarcinoma with infiltration of immunoglobulin G4-positive plasma cells and obliterative phlebitis. Conclusions: To date, there have been only few reports on the coexistence of immunoglobulin G4-related disease and lung cancer; here, we report such a rare case. Histologic examination should be considered in cases of suspicious immunoglobulin G4-related disease appearing in a lung nodule. © 2016 Tashiro et al.

引用

共 10 条

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