Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer

被引:0
作者
Ying-Fang Sun
Jyh-Der Leu
Su-Mei Chen
I-Feng Lin
Yi-Jang Lee
机构
[1] National Yang-Ming University,Department of Biomedical Imaging and Radiological Sciences
[2] Taipei City Hospital Ren Ai Branch,Division of Radiation Oncology
[3] Taipei City Hospital Ren Ai Branch,Division of Nuclear Medicine
[4] National Yang-Ming University,Department of Public Health
来源
BMC Cancer | / 9卷
关键词
Breast Cancer; Breast Cancer Case; Sporadic Breast Cancer; Taiwanese Population; Oral Contraceptive Usage;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 246 条
[1]  
Bond GL(2004)A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans Cell 119 591-602
[2]  
Hu W(1999)Regulation of the p53 protein by the MDM2 oncoprotein – thirty-eighth G.H.A. Clowes Memorial Award Lecture Cancer Res 59 1-7
[3]  
Bond EE(2006)MDM2 SNP309 accelerates colorectal tumour formation in women J Med Genet 43 950-952
[4]  
Robins H(2007)MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling Breast Cancer Res Treat 104 153-157
[5]  
Lutzker SG(2007)MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent Breast Cancer Res Treat 111 497-504
[6]  
Arva NC(2008)MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population Carcinogenesis 29 754-761
[7]  
Bargonetti J(2007)MDM2 SNP309 and cancer risk: a combined analysis Carcinogenesis 28 2262-2267
[8]  
Bartel F(2007)Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium Cancer Res 67 9584-9590
[9]  
Taubert H(2008)Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women Ann Epidemiol 18 48-57
[10]  
Wuerl P(2008)MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism BMC Cancer 8 281-246