Correlation between lead exposure and cognitive function in 12-year-old children: a systematic review and meta-analysis

被引：0
作者：
Serve Heidari
Shayan Mostafaei
Nazanin Razazian
Mojgan Rajati
Anahita Saeedi
Fatemeh Rajati
机构：
[1] Shahid Beheshti University of Medical Sciences,Department of Biostatistics, Faculty of Paramedical Sciences
[2] Kermanshah University of Medical Sciences,Department of Biostatistics, Faculty of Health
[3] Tehran University of Medical Sciences,Epidemiology of Biostatistics Unit, Rheumatology Research Center
[4] Kermanshah University of Medical Sciences,Department of Neurology, School of Medicine Imam Reza Hospital
[5] Motazedi Hospital Kermanshah University of Medical Sciences,Obstetrics and Gynecology, Department of Obstetrics and Gynecology, School of Medicine
[6] University of Massachusetts,Department of Biostatistics, School of Public Health & Health Sciences
[7] Kermanshah University of Medical Sciences,Research Center for Environmental Determinants of Health, Health Institute
来源：
Environmental Science and Pollution Research | 2021年 / 28卷
关键词：
Meta-analysis; Lead; Child; Cognition; Correlation of data; Systematic review;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Lead exposure as a toxic material especially in children can be recognized as a harmful factor for cognitive function system. This meta-analysis was conducted to estimate the lead exposure effect on cognitive function among 6979 children less than 12 years. The 16 studies were divided into two clusters according to “duration of exposure” and “dose” using k-means partitioning clustering algorithm. Then, subgroup analysis has been performed based on the clustered studies. According to the results of the k-means clustering, dose and duration of exposure were significant factors between all considered variables. A stronger negative significant pooled correlation was observed in higher dose and duration cluster in comparison with another cluster including lower dose and duration (r = − 0.29, P-value < 0.001 vs. r = − 0.08, P-value < 0.001). Overall, a negative significant correlation was observed between lead exposure and cognitive function test score (r = − 0.22, P-value < 0.001). This study confirms the negative effect of lead on cognitive function in children, but needed further investigations to achieve the safe dose and duration of the lead exposure.
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页码：43064 / 43073
页数：9
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