Gender dysphoria in children and adolescents: an overview

被引：0
作者：
Nicos Skordis
Andreas Kyriakou
Shai Dror
Avital Mushailov
Nicolas C. Nicolaides
机构：
[1] Paedi Center for Specialized Pediatrics,Division of Pediatric Endocrinology
[2] St George’s,Developmental Endocrinology Research Group
[3] University London Medical Program at the University of Nicosia Medical School,Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics
[4] School of Medicine,Division of Endocrinology and Metabolism, Center of Clinical
[5] University of Glasgow,undefined
[6] National and Kapodistrian University of Athens Medical School,undefined
[7] “Aghia Sophia” Children’s Hospital,undefined
[8] Experimental Surgery and Translational Research,undefined
[9] Biomedical Research Foundation of the Academy of Athens,undefined
来源：
Hormones | 2020年 / 19卷
关键词：
Gender dysphoria; Adolescents; Genetics; Cross-hormone treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Over the last decade, we have witnessed considerable progress in gender dysphoria (GD) terminology in an attempt to better describe the condition based on certain criteria. The ever-increasing social acceptance and destigmatization of children and adolescents with GD have resulted in an increased number of transgender individuals seeking endocrine care. In addition to terminology and diagnostic criteria, the tremendous progress of genetics and neuroimaging has enabled us to have a deeper understanding of the complex pathogenesis of GD. Although helpful guidelines for treatment with GnRH analogs and gender-affirming hormones have been proposed, several challenges and controversies still exist. In this article, the current knowledge about GD in adolescents is reviewed, with particular emphasis on terminology, clinical manifestations, and epidemiologic data. The neurobiological basis of the condition is presented, and both hormonal treatment and mental issues of transgender individuals are discussed. Undoubtedly, further research will optimize the diagnostic and therapeutic approach of children and adolescents with GD.
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页码：267 / 276
页数：9
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