Effect of D-amino acids on some mitochondrial functions in rat liver

被引：0

作者：

J. C. González-Hernández

L. Aguilera-Aguirre

V. Pérez-Vázquez

J. Ramírez

M. Clemente-Guerrero

C. Cortés-Rojo

A. Saavedra-Molina

机构：

[1] Instituto de Investigaciones Químico-Biológicas,

[2] Universidad Michoacana de San Nicolás de Hidalgo,undefined

[3] Morelia,undefined

[4] Mich. México,undefined

来源：

Amino Acids | 2003年 / 24卷

关键词：

Keywords: Mitochondria; Liver; D-Amino acids; Membrane potential; Mitochondrial Swelling; Free radicals;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.

引用

页码：163 / 169

页数：6

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