Effect of D-amino acids on some mitochondrial functions in rat liver

被引：0
|
作者：
J. C. González-Hernández
L. Aguilera-Aguirre
V. Pérez-Vázquez
J. Ramírez
M. Clemente-Guerrero
C. Cortés-Rojo
A. Saavedra-Molina
机构：
[1] Instituto de Investigaciones Químico-Biológicas,
[2] Universidad Michoacana de San Nicolás de Hidalgo,undefined
[3] Morelia,undefined
[4] Mich. México,undefined
来源：
Amino Acids | 2003年 / 24卷
关键词：
Keywords: Mitochondria; Liver; D-Amino acids; Membrane potential; Mitochondrial Swelling; Free radicals;
D O I：
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中图分类号：
学科分类号：
摘要：
 We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (ΔΨ) was decreased in the presence of 1 μM Ca2+. The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.
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页码：163 / 169
页数：6
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