Oncocytic variant, a novel subtype of chromophobe renal cell carcinoma: a report of two cases and a literature review

被引：0
作者：
Takashi Karashima
Naoto Kuroda
Takahiro Taguchi
Hideo Fukuhara
Takahira Kuno
Kenji Tamura
Makoto Hiroi
Keiji Inoue
Tadanori Yamaguchi
机构：
[1] Kochi University,Department of Urology, Kochi Medical School
[2] Kochi Red Cross Hospital,Department of Diagnostic Pathology
[3] Kochi University,Human Health and Medical Science, Faculty of Medicine
[4] Kochi Medical School Hospital,Laboratory of Diagnostic Pathology
[5] Ayabe City Hospital,Department of Cytopathology
来源：
International Cancer Conference Journal | 2021年 / 10卷
关键词：
Chromophobe renal cell carcinoma; Oncocytoma; Oncocytic variant;
D O I：
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摘要：
A novel variant of chromophobe renal cell carcinoma showing an oncocytic phenotype is proposed. Two new cases of this rare entity are presented and discussed along with six previous cases from our colleagues. A 76-year-old man and a 78-year-old man had a 3.4-cm and a 3.2-cm-diameter renal mass, respectively. On histopathological examination of surgical specimens, uniform eosinophilic cuboidal cells without a perinuclear halo growing in a tubular pattern were seen, and differential diagnosis from oncocytoma was necessary. Immunohistochemical staining for cytokeratin 7 and E-cadherin showed diffusely positive patterns in both, as in the previous reports. Although monosomy of chromosomes 7, 10, 13, and 17 was commonly observed in the previous reports, gains of chromosome 19 were observed in the two present cases. Immunohistochemical and cytogenetic approaches lead to exclusion of oncocytoma and the diagnosis of an oncocytic variant of chromophobe renal cell carcinoma.
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页码：100 / 106
页数：6
相关论文
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