Effect of Chronic Caffeine Consumption on Changes in Locomotor Activity of WAG/G and Fischer-344 Rats Induced by Nicotine, Ethanol, and Morphine

被引：0
作者：
S. K. Sudakov
I. V. Rusakova
O. F. Medvedeva
机构：
[1] Russian Ministry of Health,National Research Center for Narcology
[2] Institute of Human Morphology,Russian Academy of Medical Sciences
来源：
Bulletin of Experimental Biology and Medicine | 2003年 / 136卷
关键词：
rats; locomotor activity; caffeine; nicotine; ethanol; morphine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the effect of single treatment with nicotine, ethanol, and morphine on locomotor activity of WAG/G and Fischer-344 rats chronically drinking caffeine solution. In Fischer-344 rats receiving caffeine locomotor activity in the open-field test was much lower than in animals drinking water, while in WAG/G rats no differences in locomotor activity were found. Chronic caffeine intake increased rat sensitivity to the stimulating effect of nicotine and ethanol, but decreased their sensitivity to the depressant effect of morphine. Chronic caffeine treatment most significantly modulated the effects of nicotine, ethanol, and morphine in Fischer-344 rats.
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页码：563 / 565
页数：2
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