Semi-Synthesis and Cellular Effects of Three Different Ginsenosides Derived from Re, Rh1, and PPT

被引：0

作者：

Hongda Ding

Yanping Chen

Shuang Chen

Man Man Li

Zhao Yi Tan

Zhen Yao Lu

Pengfei Zhang

Wei Gao

Yan Xu

Fangfei Xu

Zhicai Wang

机构：

[1] Jilin University,Department of Chemistry

[2] Jilin Shulan 20 Middle School of Jilin,The Key Laboratory of Drug Metabolism and Pharmacokinetics

[3] China Pharmaceutical University,undefined

[4] Jian Pharmaceutical Co.,undefined

[5] Ltd,undefined

来源：

Chemistry of Natural Compounds | 2019年 / 55卷

关键词：

ginsenoside; semi-synthesis; NMR spectra; triterpenoid; activity studies;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

3β,12β,25-Trihydroxydammar-(E/Z)-20(22)-ene-6-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside, 3β,2β,25-trihydroxydammar-(E/Z)-20(22)-ene-6-O-β-D-glucopyranoside, and dammar-20(22)-ene-3,6,12,25-tetrol(3β,6β,12β,20E/Z) were synthesized from the ginsenosides Re, Rh1, and PPT, respectively, via a simple three-step process involving acetylation, elimination-addition, and saponification. We obtained the detailed structures of these compounds by 1D and 2D NMR, and by HR-ESI-MS. Among them, dammar-20(22)-ene-3,6,12,25-tetrol(3β,6β,12β,20Z) was identified as a new triterpenoid ginsenoside. The cytotoxic and hemolytic effects of these compounds towards cancer cells and erythrocytes were also evaluated.

引用

页码：66 / 73

页数：7

共 39 条

[1] Cho IH(2012)undefined J. Agric. Food. Chem. 60 7616-undefined
[2] Lee HJ(1981)undefined J. Nat. Prod. 44 401-undefined
[3] Kim YS(1998)undefined Phytomed. Eur. 16 221-undefined
[4] Tani T(2009)undefined Curr. Vasc. Pharmacol. 17 293-undefined
[5] Kubo M(2010)undefined J. Ethnopharmacol. 127 118-undefined
[6] Katsuki T(2009)undefined Phytochem. Lett. 2 63-undefined
[7] Hinashino M(2013)undefined J. Agric. Food. Chem. 61 9185-undefined
[8] Teruaki H(2009)undefined Chin. Chem. Lett. 20 687-undefined
[9] Sticher O(2007)undefined J. Nat. Prod. 70 1203-undefined
[10] Lu JM(2015)undefined J. Phytochem. Lett. 20 13-undefined

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