The Future of B-Cell Lymphoma Therapy: The B-Cell Receptor and its Downstream Pathways

被引：0
作者：
Vaishalee P. Kenkre
Brad S. Kahl
机构：
[1] University of Wisconsin,Department of Medicine, Division of Hematology/Oncology
[2] University of Wisconsin,undefined
[3] University of Wisconsin School of Medicine and Public Health,undefined
[4] UW Carbone Cancer Center,undefined
来源：
Current Hematologic Malignancy Reports | 2012年 / 7卷
关键词：
Non-Hodgkin lymphoma; B cell receptor; Targeted therapy; Spleen tyrosine kinase (Syk); Bruton’s tyrosine kinase (BTK); phosphoinositide 3-kinase (PI3K);
D O I：
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中图分类号：
学科分类号：
摘要：
It is becoming increasingly apparent that tonic signaling through the B cell receptor provides a growth and survival signal in many types of B cell lymphomas, and that disruption of B cell receptor signaling can be lethal to malignant B cells. Several small molecule tyrosine kinase inhibitors, which block signaling pathways downstream from the B cell receptor, are in active clinical development. Preliminary data suggests impressive activity in relapsed and refractory B cell lymphomas. Among the kinases which have been targeted are Spleen tyrosine kinase (Syk), the Bruton’s tyrosine kinase (BTK), and phosphoinositide 3-kinase (PI3K). This article discusses the rationale for targeting these pathways and summarizes the current clinical trial data for agents targeting Syk, BTK, and PI3K.
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页码：216 / 220
页数：4
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