Voxel-based morphometry and task functional magnetic resonance imaging in essential tremor: evidence for a disrupted brain network

被引:0
作者
Ilaria Boscolo Galazzo
Francesca Magrinelli
Francesca Benedetta Pizzini
Silvia Francesca Storti
Federica Agosta
Massimo Filippi
Angela Marotta
Giancarlo Mansueto
Gloria Menegaz
Michele Tinazzi
机构
[1] University of Verona,Department of Computer Science
[2] University of Verona,Department of Neurosciences, Biomedicine and Movement Sciences, Neurology Section
[3] University of Verona,Department of Diagnostics and Pathology
[4] Vita-Salute San Raffaele University,Neuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute
来源
Scientific Reports | / 10卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
The pathophysiology of essential tremor (ET) is controversial and might be further elucidated by advanced neuroimaging. Focusing on homogenous ET patients diagnosed according to the 2018 consensus criteria, this study aimed to: (1) investigate whether task functional MRI (fMRI) can identify networks of activated and deactivated brain areas, (2) characterize morphometric and functional modulations, relative to healthy controls (HC). Ten ET patients and ten HC underwent fMRI while performing two motor tasks with their upper limb: (1) maintaining a posture (both groups); (2) simulating tremor (HC only). Activations/deactivations were obtained from General Linear Model and compared across groups/tasks. Voxel-based morphometry and linear regressions between clinical and fMRI data were also performed. Few cerebellar clusters of gray matter loss were found in ET. Conversely, widespread fMRI alterations were shown. Tremor in ET (task 1) was associated with extensive deactivations mainly involving the cerebellum, sensory-motor cortex, and basal ganglia compared to both tasks in HC, and was negatively correlated with clinical tremor scales. Homogeneous ET patients demonstrated deactivation patterns during tasks triggering tremor, encompassing a network of cortical and subcortical regions. Our results point towards a marked cerebellar involvement in ET pathophysiology and the presence of an impaired cerebello-thalamo-cortical tremor network.
引用
收藏
相关论文
共 122 条
[1]  
Bhatia KP(2018)Consensus statement on the classification of tremors from the task force on tremor of the International Parkinson and Movement Disorder Society Mov. Disord. 33 75-87
[2]  
Louis ED(2020)Essential tremor-plus: a controversial new concept Lancet Neurol. 19 266-270
[3]  
Louis ED(2010)How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor Mov. Disord. 25 534-541
[4]  
Ferreira JJ(2013)The pathophysiology of essential tremor and Parkinson's tremor Curr. Neurol. Neurosci. Rep. 13 378-35
[5]  
Helmich RC(2016)Knowledge gaps and research recommendations for essential tremor Parkinsonism Relat. Disord. 33 27-242
[6]  
Toni I(2016)Linking essential tremor to the cerebellum: neuropathological evidence Cerebellum 15 235-275
[7]  
Deuschl G(2016)Linking essential tremor to the cerebellum-neuroimaging evidence Cerebellum 15 263-64
[8]  
Bloem BR(2012)The oscillating central network of Essential tremor Clin. Neurophysiol. 123 61-231
[9]  
Hopfner F(2014)Neuroimaging essentials in essential tremor: a systematic review Neuroimage Clin. 5 217-2063
[10]  
Louis ED(2018)A voxel-wise meta-analysis of gray matter abnormalities in essential tremor Front. Neurol. 9 495-6642