PPAR-γ agonists and diabetic nephropathy

被引：25
作者：
Zhang Y. [1 ]
Guan Y. [1 ]
机构：
[1] Division of Nephrology and Hypertension, Vanderbilt University Medical Center, Nashville
来源：
Current Diabetes Reports | 2005年 / 5卷 / 6期
关键词：
Diabetic Nephropathy; Rosiglitazone; Pioglitazone; Mesangial Cell; Troglitazone;
D O I：
10.1007/s11892-005-0057-5
中图分类号：
学科分类号：
摘要：
Diabetic nephropathy is a clinical syndrome of albuminuria, declining glomerular filtration rate, and increased risk of cardiovascular disease. Multiple mechanisms have been implicated in its pathogenesis. Although current therapies appear to be effective, treatment of diabetic nephropathy remains suboptimal. This review summarizes the recently emerging evidence suggesting that peroxisome proliferator-activated receptor-γ agonists may prove to be effective therapeutic agents in the treatment of diabetic renal complications. Copyright © 2005 by Current Science Inc.
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收藏
页码：470 / 475
页数：5
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