Novel insights into NOD-like receptors in renal diseases

被引：0
作者：
Juan Jin
Tao-jie Zhou
Gui-ling Ren
Liang Cai
Xiao-ming Meng
机构：
[1] Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Department of Pharmacy
[2] Anhui Institute of Innovative Drugs,undefined
[3] School of Pharmacy,undefined
[4] Anhui Medical University,undefined
[5] The Key Laboratory of Anti-Inflammatory of Immune Medicines,undefined
[6] Ministry of Education,undefined
[7] School of Basic Medicine,undefined
[8] Anhui Medical University,undefined
[9] Second Clinical Medical College,undefined
[10] Anhui Medical University,undefined
[11] The 901 Hospital of Chinese People’s Liberation Army Joint Service Support Unit,undefined
来源：
Acta Pharmacologica Sinica | 2022年 / 43卷
关键词：
NOD-like receptors; innate immunity; inflammasome; renal disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Nucleotide-binding oligomerization domain-like receptors (NLRs), including NLRAs, NLRBs (also known as NAIPs), NLRCs, and NLRPs, are a major subfamily of pattern recognition receptors (PRRs). Owing to a recent surge in research, NLRs have gained considerable attention due to their involvement in mediating the innate immune response and perpetuating inflammatory pathways, which is a central phenomenon in the pathogenesis of multiple diseases, including renal diseases. NLRs are expressed in different renal tissues during pathological conditions, which suggest that these receptors play roles in acute kidney injury, obstructive nephropathy, diabetic nephropathy, IgA nephropathy, lupus nephritis, crystal nephropathy, uric acid nephropathy, and renal cell carcinoma, among others. This review summarises recent progress on the functions of NLRs and their mechanisms in the pathophysiological processes of different types of renal diseases to help us better understand the role of NLRs in the kidney and provide a theoretical basis for NLR-targeted therapy for renal diseases.
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页码：2789 / 2806
页数：17
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