Collagen scaffolds for orthopedic regenerative medicine

被引：0
作者：
Gráinne M. Cunniffe
Fergal J. O’Brien
机构：
[1] Royal College of Surgeons in Ireland,Department of Mechanical and Manufacturing Engineering
[2] Royal College of Surgeons in Ireland,Department of Anatomy
[3] Trinity College,Trinity Centre for Bioengineering
来源：
JOM | 2011年 / 63卷
关键词：
Chitosan; Tissue Engineering; Bone Tissue Engineering; Collagen Molecule; Composite Scaffold;
D O I：
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中图分类号：
学科分类号：
摘要：
Collagen and collagen-based scaffolds offer distinct advantages when selected as biomaterials for use across a broad spectrum of regenerative medicine applications. However, relatively poor mechanical properties are often perceived to limit their usefulness for orthopedic applications. These problems can be overcome through enhanced crosslinking mechanisms or through the addition of a second, stiffer phase such as hydroxyapatite, thus allowing tailored composite scaffolds to meet specific tissue requirements. This overview will highlight the current state of the art of these scaffolds, and consider the exciting prospects and future directions of collagen-based technologies for orthopedic regenerative medicine.
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