The γ-Subunit of the Rod Photoreceptor cGMP-Binding cGMP-Specific PDE is Expressed in Mouse Lung

被引：13
作者：
Tate R.J. [2 ]
Lochhead A. [1 ]
Brzeski H. [2 ]
Arshavsky V. [3 ]
Pyne N.J. [1 ]
机构：
[1] Department of Physiology, University of Strathclyde, 204 George St, Glasgow
[2] Molecular Biology Laboratory, University of Strathclyde, 204 George St, Glasgow
[3] Harvard Medical School, Howe Laboratory of Ophthalmology, Boston, MA
来源：
Cell Biochemistry and Biophysics | 1998年 / 29卷 / 1-2期
关键词：
Lung; PDE-5; PDE-6; Phosphodiesterase; γ-subunit;
D O I：
10.1007/BF02737832
中图分类号：
学科分类号：
摘要：
The type 6 phosphodiesterase (PDE-6) from retinal rod photoreceptors is an αβγ2 heterotetramer. The α- and β-subunits contain catalytic sites for cGMP hydrolysis, whereas the γ-subunits (Pγ) serve as a protein inhibitor of the enzyme. Pγ is believed to be expressed only in photoreceptors. Using RT-PCR, we have amplified the complete coding sequence for Pγ from mouse lung RNA. The expression of Pγ in this tissue may be related to its ability to interact the type 5 phosphodiesterase (PDE-5), which is the predominant cGMP binding protein in lung. We therefore suggest that Pγ may have a wider signaling role in mammalian cells than previously appreciated.
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页码：133 / 144
页数：11
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