Cardiovascular risks of androgen deprivation therapy for prostate cancer

被引：1

作者：

Miller, K. ^{[1
]}

机构：

[1] Klin & Hsch Ambulanz Urol, Charitepl 1, D-10117 Berlin, Germany

来源：

UROLOGE | 2016年 / 55卷 / 05期

关键词：

Prostate cancer; Androgen deprivation therapy; Cardio vascular events; GnRH antagonists; LHRH agonists; MEN; DISEASE; ASSOCIATION; SUPPRESSION; MORBIDITY; MORTALITY;

D O I：

10.1007/s00120-015-0021-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Androgen deprivation therapy (ADT) is the standard treatment for metastatic prostate cancer. It has increasingly been used in other stages of the disease as well. Besides well-known side effects caused by the lack of testosterone (impotency, osteoporosis, fatigue, loss of muscle mass), an increase of cardiovascular (CV) morbidity and mortality has recently been discussed in association with ADT. Cardiovascular side effects cannot be sufficiently explained by low testosterone levels. This review gives an overview of the recent literature, interprets the results, and offers clinical consequences.

引用

页码：627 / 631

页数：5

共 29 条

[1] Cardiovascular Morbidity Associated with Gonadotropin Releasing Hormone Agonists and an Antagonist [J].

Albertsen, Peter C. ;

Klotz, Laurence ;

Tombal, Bertrand ;

Grady, James ;

Olesen, Tine K. ;

Nilsson, Jan .

EUROPEAN UROLOGY, 2014, 65 (03) :565-573

[2]

[Anonymous], 2022, CLUST DEUTSCHL

[3] Lifestyle Changes for Improving Disease-specific Quality of Life in Sedentary Men on Long-term Androgen-Deprivation Therapy for Advanced Prostate Cancer: A Randomised Controlled Trial [J].

Bourke, Liam ;

Gilbert, Stephen ;

Hooper, Richard ;

Steed, Liz A. ;

Joshi, Miland ;

Catto, Jim W. F. ;

Saxton, John M. ;

Rosario, Derek J. .

EUROPEAN UROLOGY, 2014, 65 (05) :865-872

[4] Cardiovascular events associated with androgen deprivation therapy in patients with prostate cancer: a systematic review and meta-analysis [J].

Carneiro, Arie ;

Sasse, Andre Deeke ;

Wagner, Andrew Aurel ;

Peixoto, Guilherme ;

Kataguiri, Andre ;

Serpa Neto, Ary ;

Vieira Bianco, Bianca Alves ;

Chang, Peter ;

Lima Pompeo, Antonio Carlos ;

Tobias-Machado, Marcos .

WORLD JOURNAL OF UROLOGY, 2015, 33 (09) :1281-1289

[5] Human peripheral blood mononuclear cells express gonadotropin-releasing hormone (GnRH), GnRH receptor, and interleukin-2 receptor γ-chain messenger ribonucleic acids that are regulated by GnRH in vitro [J].

Chen, HF ;

Jeung, EB ;

Stephenson, M ;

Leung, PCK .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (02) :743-750

[6] Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions [J].

D'Amico, Anthony V. ;

Denham, James W. ;

Crook, Juanita ;

Chen, Ming-Hui ;

Goldhaber, Samuel Z. ;

Lamb, David S. ;

Joseph, David ;

Tai, Keen-Hun ;

Malone, Shawn ;

Ludgate, Charles ;

Steigler, Allison ;

Kantoff, Philip W. .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (17) :2420-2425

[7]

[DKG DeutscheKrebshilfe AWMF], DIAGN THER DERV STAD

[8] Cardiovascular Mortality and Duration of Androgen Deprivation for Locally Advanced Prostate Cancer: Analysis of RTOG 92-02 [J].

Efstathiou, Jason A. ;

Bae, Kyounghwa ;

Shipley, William U. ;

Hanks, Gerald E. ;

Pilepich, Miljenko V. ;

Sandler, Howard M. ;

Smith, Matthew R. .

EUROPEAN UROLOGY, 2008, 54 (04) :816-824

[9] Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review [J].

Gardner, Jason R. ;

Livingston, Patricia M. ;

Fraser, Steve F. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (04) :335-+

[10] Androgen Deprivation Therapy and Cardiovascular Risk in Chinese Patients with Nonmetastatic Carcinoma of Prostate [J].

Huang, Gang ;

Yeung, Chun-Yip ;

Lee, Ka Kui ;

Liu, Jianxiong ;

Ho, Kwan Lun ;

Yiu, Ming-Kwong ;

Lam, Karen Siu-Ling ;

Tse, Hung-Fat ;

Yau, Thomas ;

Siu, Chung-Wah .

JOURNAL OF ONCOLOGY, 2014, 2014

← 1 2 3 →