pH-sensitive Nanoparticles for High Loading and Efficient Delivery of Doxorubicin

被引：0
作者：
Mengli Lu
Lihua Huang
Siwen Zhan
Juncan Li
Tong Qiu
Mengjia Yang
Jie Li
Miao Tong
Xueqiong Zhang
Chuan Shi
机构：
[1] Wuhan University of Technology,School of Chemistry, Chemical Engineering and Life Sciences
[2] Huazhong University of Science and Technology,Tongji Medical College
[3] Wuhan Aimin Pharmaceutical Co. Ltd,undefined
[4] Hubei Li Shizhen Pharmaceutical Research Co. Ltd,undefined
来源：
Journal of Wuhan University of Technology-Mater. Sci. Ed. | 2023年 / 38卷
关键词：
nanoparticles; acylhydrazone bond; polymeric prodrug; acid-sensitive;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
An acid-sensitive delivery system based on acylhydrazone bond was developed for high loading and efficient delivery of doxorubicin. Doxorubicin(DOX) was covalently combined with dihydrazide adipate to form acid-sensitive hydrazone bond based on Schiff base reaction, then the intermediate was covalently combined with carboxymethyl chitosan through amide bond to form polymeric prodrugs, and nanoparticles were formed through self-assembling. Moreover, the structural and particle properties of CMCS-ADH-DOX were characterized by ultraviolet visible near infrared spectrophotometry (UV), nuclear magnetic resonance spectroscopy (1H-NMR), fourier transform infrared spectroscopy (FT-IR), dynamic light scattering (DLS), and transmission electron microscopy (TEM). The mean diameter of the self-assembled nanoparticles is 165 nm, while the morphology is a relatively uniform spherical shape. Moreover, these DOX-loaded nanoparticles showed pH-triggered drug release behavior. Compared with free DOX, CAD NPs showed lower toxic side effects in L929 cells and similar toxicity in 4T1 cells. The experimental results indicate that the CMCS-ADH-DOX nanoparticles may be used as an acid-sensitive targeted delivery system with good application prospect for cancer.
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页码：929 / 937
页数：8
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