Between a rock and a hard place?

被引：0
作者：
Adrian Whitty
Gnanasambandam Kumaravel
机构：
[1] Biogen Idec,the Drug Discovery Department
[2] Inc.,undefined
[3] 14 Cambridge Center,undefined
来源：
Nature Chemical Biology | 2006年 / 2卷
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摘要：
Developing small-molecule inhibitors against protein-protein interaction targets is among the most difficult challenges in contemporary drug discovery. Recent developments in our understanding of this problem, and in the knowledge and tools available to address it, give cause for renewed hope, but substantial challenges remain.
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页码：112 / 118
页数：6
相关论文
共 64 条
[1]  
Cochran A(2000)undefined Chem. Biol. 7 R85-R94
[2]  
Toogood PL(2002)undefined J. Med. Chem. 45 1543-1558
[3]  
Arkin MR(2004)undefined Nat. Rev. Drug Discov. 3 301-317
[4]  
Wells JA(2005)undefined Drug Design Rev. 2 179-207
[5]  
Fisher PM(2002)undefined Comb. Chem. High Throughput Screen. 5 613-621
[6]  
Hajduk PJ(2005)undefined Autoimmun. Rev. 4 537-541
[7]  
Burns DJ(1997)undefined Adv. Drug Deliv. Rev. 23 3-25
[8]  
Puppo F(1975)undefined Adv. Enz. Rel. Areas Molec. Biol. 43 219-410
[9]  
Murdaca G(1995)undefined Science 267 383-386
[10]  
Ghio M(2003)undefined Proc. Natl. Acad. Sci. USA 100 1603-1608
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