Effects of GABA-transaminase inhibitor Vigabatrin on thermoregulation in rats

被引：0
作者：
Rumen P. Nikolov
Krassimira S. Yakimova
机构：
[1] Medical University,Department of Pharmacology and Toxicology, Faculty of Medicine
来源：
Amino Acids | 2011年 / 40卷
关键词：
GABA; Vigabatrin; Thermoregulation; PO/AH neurons; Rats;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Vigabatrin is a GABA derivative (gamma-vinyl GABA) which inhibits irreversibly the enzyme activity of GABA transaminase and thus increased indirectly brain GABA concentrations. We have used body temperature assay to examine the effects of Vigabatrin on thermoregulation in intact rats. In order to understand the mechanism of thermoregulatory action of Vigabatrin at cellular level, we have investigated its effect on individual warm-sensitive preoptic area/anterior hypothalamus (PO/AH) neurons in rat brain slice preparations. The results of the present study suggest that Vigabatrin produced dose-dependent hypothermia in rats and also increased temperature sensitivity of warm-sensitive PO/AH neurons.
引用
收藏
页码：1441 / 1445
页数：4
相关论文
共 99 条
[1]  
Aicardi J(1996)Vigabatrin as initial therapy for infantile spasms: European retrospective survey Epilepsia 37 638-642
[2]  
Mumford J(2005)Safety and efficacy of gamma-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction Synapse 55 122-125
[3]  
Dumas C(1983)A review of terms for regulated vs. forced, neurochemical-induced changes in body temperature Life Sci 32 1285-1295
[4]  
Wood S(1989)Experimental studies of the influence of vigabatrin on the GABA system Br J Clin Pharmacol 27 13-17
[5]  
Brodie JD(1993)Co-distribution of GABA- with acetylcholine-synthesizing neurons in the basal forebrain of the rat J Comp Neurol 329 438-457
[6]  
Figueroa E(1991)An update on thermosensitive neurons in the brain: from cellular biology to thermal and non-thermal homeostatic functions Jpn J Physiol 41 1-22
[7]  
Laska EM(2003)Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test Methods Find Exp Clin Pharmacol 25 265-271
[8]  
Dewey SL(1986)Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurons and astrocytes Neuropharmacology 25 617-625
[9]  
Gordon CJ(2001)Vigabatrin visual toxicity: evolution and dose dependence Epilepsia 42 609-615
[10]  
Gram L(1994)Vigabatrin: effects on human brain GABA levels by nuclear magnetic resonance spectroscopy Epilepsia 35 29-32
12345678910